abstract：AIMS:Outcomes of colorectal cancer (CRC) treatment and survival have steadily improved during the past decades, accompanied by an increased risk of developing second primary tumours and metastatic tumours at unusual sites. Metastatic CRC can show mucosal colonisation, thereby mimicking a second primary tumour. This pot...

journal_title：Histopathology

authors： de Bitter TJJ,van der Linden RLA,van Vliet S,Weren F,Sie D,Ylstra B,van der Linden HC,Knijn N,Ligtenberg MJL,van der Post RS,Simmer F,Nagtegaal ID

更新日期：2019-09-01 00:00:00

abstract：AIMS:Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia-associated transcription factor family on chromosome Xp11.2. Dual-colour break-apart fluorescence in-situ hybridisation (FISH) is recommended to confir...

journal_title：Histopathology

authors： Kato I,Furuya M,Baba M,Kameda Y,Yasuda M,Nishimoto K,Oyama M,Yamasaki T,Ogawa O,Niino H,Nakaigawa N,Yano Y,Sakamoto K,Urata Y,Mikami K,Yamasaki S,Tanaka R,Takagi T,Kondo T,Nagashima Y

更新日期：2019-08-01 00:00:00

abstract：AIM:To describe a group of distinct low-grade oncocytic renal tumours that demonstrate CD117 negative/cytokeratin (CK) 7-positive immunoprofile. METHODS AND RESULTS:We identified 28 such tumours from four large renal tumour archives. We performed immunohistochemistry for: CK7, CD117, PAX8, CD10, AMACR, e-cadherin, CK2...

journal_title：Histopathology

authors： Trpkov K,Williamson SR,Gao Y,Martinek P,Cheng L,Sangoi AR,Yilmaz A,Wang C,San Miguel Fraile P,Perez Montiel DM,Bulimbasić S,Rogala J,Hes O

更新日期：2019-08-01 00:00:00

abstract：AIMS:Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, in which turnaround tim...

journal_title：Histopathology

authors： French JMR,Betney DT,Abah U,Bhatt N,Internullo E,Casali G,Batchelor TJP,West DG

更新日期：2019-05-01 00:00:00

abstract：AIMS:SMAD4 acts as a tumour suppressor, and the loss of SMAD4 is associated with poor prognosis in colorectal cancer (CRC) patients. Although next-generation sequencing (NGS) enabled us to detect numerous genetic alterations in a single assay, the clinical significance of SMAD4 alteration detected with NGS has not been...

journal_title：Histopathology

authors： Oyanagi H,Shimada Y,Nagahashi M,Ichikawa H,Tajima Y,Abe K,Nakano M,Kameyama H,Takii Y,Kawasaki T,Homma KI,Ling Y,Okuda S,Takabe K,Wakai T

更新日期：2019-05-01 00:00:00

abstract：AIMS:There is evidence that four or five gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to address this gap by assessing the number of biopsies required to g...

journal_title：Histopathology

authors： Kaye P,Lindsay D,Madhusudan S,Vohra R,Catton J,Platt C,Ragunath K

更新日期：2019-05-01 00:00:00

abstract：AIMS:Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in gallbladder tissues. I...

journal_title：Histopathology

authors： Espinoza JA,Riquelme I,Sagredo EA,Rosa L,García P,Bizama C,Apud-Bell M,Leal P,Weber H,Benavente F,Vargas S,Romero D,Kalergis AM,Roa JC

更新日期：2019-03-01 00:00:00

abstract：AIMS:SOX11 is known as an essential transcription factor for regulating neurogenesis. Recently, SOX11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (MCL). However, SOX11 expression in other tumour types has not yet been extensively studied. METH...

journal_title：Histopathology

authors： Xu S,Dong Y,Huo Z,Yu L,Xue J,Wang G,Duan Y

更新日期：2019-02-01 00:00:00

abstract：AIM:Primary cutaneous neuroendocrine carcinoma, or Merkel cell carcinoma (MCC), cannot be distinguished morphologically from small-cell neuroendocrine carcinomas (SmCC) from other sites. Immunohistochemistry is required to confirm cutaneous origin, and is also used for detection of sentinel lymph node (SLN) metastases ...

journal_title：Histopathology

authors： Stanoszek LM,Chan MP,Palanisamy N,Carskadon S,Siddiqui J,Patel RM,Harms KL,Lowe L,Fullen DR,Harms PW

更新日期：2019-02-01 00:00:00

abstract：:Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging...

journal_title：Histopathology

authors： Magers MJ,Lopez-Beltran A,Montironi R,Williamson SR,Kaimakliotis HZ,Cheng L

更新日期：2019-01-01 00:00:00

abstract：:Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon n...

journal_title：Histopathology

authors： Delahunt B,Eble JN,Egevad L,Samaratunga H

更新日期：2019-01-01 00:00:00

abstract：AIMS:The immunoregulatory enzyme indoleamine dioxygenase 2,3 (IDO) has been implicated in cervical and vulvar squamous carcinomas (SCC) and may represent a mechanism of resistance to anti-PD-1/anti-PD-L1 therapy. However, the relationship between IDO and PD-L1 has not been well-investigated. METHODS AND RESULTS:Sixty-...

journal_title：Histopathology

authors： Chinn Z,Stoler MH,Mills AM

更新日期：2019-01-01 00:00:00

abstract：AIMS:MUC4 is a transmembrane glycoprotein that plays a role in cell growth signalling and is expressed in various epithelial tissues. Gene expression profiling and immunohistochemical analyses revealed that MUC4 is also constantly and specifically expressed in low-grade fibromyxoid sarcomas and sclerosing epithelioid f...

journal_title：Histopathology

authors： Matsuyama A,Jotatsu M,Uchihashi K,Tsuda Y,Shiba E,Haratake J,Hisaoka M

更新日期：2019-01-01 00:00:00

abstract：AIMS:Since Xp11.2 translocation-associated renal cell carcinoma (TRCC) was first recognised, its morphological features and the clinical significance of TFE3 expression, frequency of gene translocation and diagnostic criteria have been the subject of limited studies. The present retrospective analysis aimed to evaluate...

journal_title：Histopathology

authors： Lee HJ,Shin DH,Kim SY,Hwang CS,Lee JH,Park WY,Choi KU,Kim JY,Lee CH,Sol MY,Rha SH,Park SW

更新日期：2018-11-01 00:00:00

abstract：AIMS:Sessile serrated adenoma/polyp (SSA/P) is regarded as a genetically homogeneous entity, with most lesions harbouring the BRAF V600E mutation. The present study aimed to reappraise the genetic heterogeneity of SSA/Ps and its clinicopathological significance. METHODS AND RESULTS:We performed next-generation sequenc...

journal_title：Histopathology

authors： Cho H,Hashimoto T,Yoshida H,Taniguchi H,Ogawa R,Mori T,Hiraoka N,Saito Y,Sekine S

更新日期：2018-10-01 00:00:00

abstract：AIMS:The diagnosis of cutaneous γδ T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Our aim in this study was, by using a new monoclonal antibody (mAb) against TCRδ, to evaluate TCRδ expression in formalin-fixed paraffin-embedded (FFPE) skin tissue from TCRγ+ cutaneous T-ce...

journal_title：Histopathology

authors： Pulitzer M,Geller S,Kumar E,Frosina D,Moskowitz A,Horwitz S,Myskowski P,Kheterpal M,Chan A,Dogan A,Jungbluth A

更新日期：2018-10-01 00:00:00

abstract：AIMS:Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates in a subset of patients suggest that a sensitive companion diagnostic test is required. The predictive value of programmed death ligand 1 (PD-L1) staining in melanoma has been questioned due to inconsist...

journal_title：Histopathology

authors： Koelzer VH,Gisler A,Hanhart JC,Griss J,Wagner SN,Willi N,Cathomas G,Sachs M,Kempf W,Thommen DS,Mertz KD

更新日期：2018-09-01 00:00:00

abstract：AIMS:Eosinophilic oesophagitis (EoE) is a chronic inflammatory disease characterised clinically by symptoms of oesophageal dysfunction and histopathologically by a prominent eosinophilic inflammation. Despite eosinophils having a histologically predominant position, their role in the immunopathogenesis of the disease i...

journal_title：Histopathology

authors： Strasser DS,Seger S,Bussmann C,Pierlot GM,Groenen PMA,Stalder AK,Straumann A

更新日期：2018-09-01 00:00:00

abstract：AIMS:CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. For reliable implementation in daily practice and meaningful selection of patients for clinical trials, information on techni...

journal_title：Histopathology

authors： Koens L,van de Ven PM,Hijmering NJ,Kersten MJ,Diepstra A,Chamuleau M,de Jong D

更新日期：2018-09-01 00:00:00

abstract：AIMS:Merkel cell carcinoma represents poorly differentiated neuroendocrine carcinoma of cutaneous origin. In most studies, the vast majority of Merkel cell carcinomas are Merkel cell polyomavirus (MCPyV)-associated. SV40 polyomavirus immunohistochemistry is typically used in the diagnosis of other polyomavirus-associat...

journal_title：Histopathology

authors： Pelletier DJ,Czeczok TW,Bellizzi AM

更新日期：2018-07-01 00:00:00

abstract：AIMS:Cystic lesions derived from the synovial and ligamentous structures of the spine have varied histological appearances. Not uncommonly, there is discrepancy between the clinicoradiological diagnosis and histology. Therefore, we sought to characterise the histological features of tissue submitted as 'synovial cysts'...

journal_title：Histopathology

authors： Chebib I,Chang CY,Schwab JH,Kerr DA,Deshpande V,Nielsen GP

更新日期：2018-05-01 00:00:00

abstract：AIMS:To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan and the association with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV). METHODS AND RESULTS:We investigated retrospectively 26 cases with a median age of 76.5. O...

journal_title：Histopathology

authors： Chen BJ,Wang RC,Ho CH,Yuan CT,Huang WT,Yang SF,Hsieh PP,Yung YC,Lin SY,Hsu CF,Su YZ,Kuo CC,Chuang SS

更新日期：2018-05-01 00:00:00

abstract：AIMS:Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. METHODS AND...

journal_title：Histopathology

authors： Yamashita K,Kohashi K,Yamada Y,Ishii T,Nishida Y,Urakawa H,Ito I,Takahashi M,Inoue T,Ito M,Ohara Y,Oda Y,Toyokuni S

更新日期：2018-04-01 00:00:00

abstract：:Extramural venous invasion (EMVI) is a well-known prognostic factor in colorectal cancer (CRC). Vascular invasion within the bowel wall, intramural vascular invasion (IMVI), has received less attention and its incidence and prognostic importance in CRC is not completely known. A systematic literature search was perfor...

journal_title：Histopathology

authors： Knijn N,van Exsel UEM,de Noo ME,Nagtegaal ID

更新日期：2018-04-01 00:00:00

abstract：AIM:To train and individually validate a group of breast pathologists in specialty-specific digital primary diagnosis by using a novel protocol endorsed by the Royal College of Pathologists' new guideline for digital pathology. The protocol allows early exposure to live digital reporting, in a risk-mitigated environmen...

journal_title：Histopathology

authors： Williams BJ,Hanby A,Millican-Slater R,Nijhawan A,Verghese E,Treanor D

更新日期：2018-03-01 00:00:00

abstract：AIMS:Genome-wide next-generation sequencing has revealed several driver mutations and has allowed the establishment of a molecular taxonomy of gastric cancer. However, there are few detailed studies on the mutational spectrum of poorly cohesive gastric carcinoma. Thus, this study aim to investigate its mutation profile...

journal_title：Histopathology

authors： Kwon CH,Kim YK,Lee S,Kim A,Park HJ,Choi Y,Won YJ,Park DY,Lauwers GY

更新日期：2018-03-01 00:00:00

abstract：AIMS:Programmed death ligand 1 (PD-L1) immunohistochemistry has become a mandatory diagnostic test in the treatment of lung cancer. Several research initiatives have started to harmonise the five PD-L1 immunohistochemistry assays that have been used in clinical trials. Here, we report data on interlaboratory and intera...

journal_title：Histopathology

authors： Scheel AH,Baenfer G,Baretton G,Dietel M,Diezko R,Henkel T,Heukamp LC,Jasani B,Jöhrens K,Kirchner T,Lasitschka F,Petersen I,Reu S,Schildhaus HU,Schirmacher P,Schwamborn K,Sommer U,Stoss O,Tiemann M,Warth A,Weichert

更新日期：2018-02-01 00:00:00

abstract：AIMS:Metastatic melanoma involving the epidermis and/or upper dermis may show significant histological overlap with primary cutaneous melanoma, especially the nodular subtype. Proper histopathological classification is crucial to appropriate staging and management, but is often challenging. The aim of this study was to...

journal_title：Histopathology

authors： Skala SL,Arps DP,Zhao L,Cha KB,Wang M,Harms PW,Andea AA,Fullen DR,Chan MP

更新日期：2018-02-01 00:00:00

abstract：AIMS:Using intraoperative frozen sections to diagnose pulmonary sclerosing pneumocytoma is always challenging. However, an accurate diagnosis is needed to guide surgical management and prevent unnecessary treatment. The aim of this study was to investigate the most frequently misdiagnosed histological patterns and eval...

journal_title：Histopathology

authors： Yang CH,Lee LY

更新日期：2018-02-01 00:00:00

abstract：AIMS:Early recognition and accurate diagnosis underpins melanoma survival. Identifying early melanomas arising in association with pre-existing lesions is often challenging. Clinically suspicious foci, however small, must be identified and examined histologically. This study assessed the accuracy of punch biopsy 'scori...

journal_title：Histopathology

authors： Grogan J,Cooper CL,Dodds TJ,Guitera P,Menzies SW,Scolyer RA

更新日期：2018-01-01 00:00:00

abstract：:Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical...

journal_title：Histopathology

authors： Acquaviva G,Visani M,Repaci A,Rhoden KJ,de Biase D,Pession A,Giovanni T

更新日期：2018-01-01 00:00:00

abstract：AIMS:Breast cancer is one of the most common cancer diseases in women, with >1.67 million cases being diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumour spreads, and it is usually located in the ipsilateral axilla. In patients with no c...

journal_title：Histopathology

authors： Holten-Rossing H,Talman MM,Jylling AMB,Laenkholm AV,Kristensson M,Vainer B

更新日期：2017-12-01 00:00:00

abstract：AIMS:In this study, we aimed to investigate the clinicopathological features of CD4+ and/or CD56+ immature haematolymphoid malignancy (iHLM), including blastic plasmacytoid dendritic cell neoplasm (BPDCN). METHODS AND RESULTS:We analysed the clinicopathological features of 46 patients diagnosed consecutively with CD4+...

journal_title：Histopathology

authors： Suzuki Y,Kato S,Kohno K,Satou A,Eladl AE,Asano N,Kono M,Kato Y,Taniwaki M,Akiyama M,Nakamura S

更新日期：2017-12-01 00:00:00

abstract：AIMS:To evaluate whether a comprehensive histological evaluation of reticulin fibrosis, collagen deposition and osteosclerosis in bone marrow trephine biopsies (BMBs) of primary myelofibrosis (PMF) patients may have prognostic implications. METHODS AND RESULTS:Reticulin fibrosis, collagen deposition and osteosclerosis...

journal_title：Histopathology

authors： Gianelli U,Fiori S,Cattaneo D,Bossi A,Cortinovis I,Bonometti A,Ercoli G,Bucelli C,Orofino N,Bulfamante G,Iurlo A

更新日期：2017-12-01 00:00:00

abstract：AIMS:Mucinous tubular and spindle cell carcinoma (MTSC) of the kidney is a distinct entity characterized by bland tightly packed elongated tubules and spindle cells with low nucleolar grade in a basophilic mucinous stroma. Several case studies have reported MTSC with high-grade features and have brought into question w...

journal_title：Histopathology

authors： Sadimin ET,Chen YB,Wang L,Argani P,Epstein JI

更新日期：2017-11-01 00:00:00

abstract：AIMS:HER2 testing of invasive breast cancer by in-situ hybridization guides therapy decisions. Probing HER2 and centromere of chromosome 17 (cen17) simultaneously is supposed to reveal both a potential HER2 gene amplification and polysomy 17. However, a considerable number of breast cancer patients with quasi polysomy ...

journal_title：Histopathology

authors： Holzschuh MA,Czyz Z,Hauke S,Inwald EC,Polzer B,Brockhoff G

更新日期：2017-10-01 00:00:00

abstract：AIMS:The clinical outcome of patients with locally advanced rectal cancer who undergo neoadjuvant chemoradiotherapy (CRT) is influenced by the tumour response to treatment, which is reflected by tumour regression grade and post-treatment (y) TNM stage. Little is known about the prognostic value of pretreatment histopat...

journal_title：Histopathology

authors： Reggiani Bonetti L,Lionti S,Domati F,Pagliani G,Mattioli E,Barresi V

更新日期：2017-09-01 00:00:00

abstract：AIMS:Tumour-infiltrating lymphocytes (TILs) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in ductal carcinoma in situ (DCIS) remains uncer...

journal_title：Histopathology

authors： Miligy I,Mohan P,Gaber A,Aleskandarany MA,Nolan CC,Diez-Rodriguez M,Mukherjee A,Chapman C,Ellis IO,Green AR,Rakha EA

更新日期：2017-08-01 00:00:00

abstract：AIM:To evaluate the intraobserver and interobserver reproducibility of the HER2 in-situ hybridization (ISH) test in breast cancer by measuring the impact of counting different numbers of invasive cancer cells. METHODS AND RESULTS:A cohort of 101 primary invasive breast cancer cases were evaluated for HER2 gene amplifi...

journal_title：Histopathology

authors： Polónia A,Eloy C,Pinto J,Braga AC,Oliveira G,Schmitt F

更新日期：2017-08-01 00:00:00

abstract：AIMS:Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase involved in glycogen metabolism, cell cycle progression, differentiation, embryogenesis, migration, metabolism, survival and cellular senescence. Its main biological function is to inhibit β-catenin by sequestration and promotion of its proteaso...

journal_title：Histopathology

authors： Agostinelli C,Carloni S,Limarzi F,Righi S,Laginestra MA,Musuraca G,Fiorentino M,Napolitano R,Cuneo A,Vergara D,Zinzani PL,Sabattini E,Pileri SA,De Matteis S

更新日期：2017-07-01 00:00:00